Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency
نویسندگان
چکیده
منابع مشابه
Deficiency for Costimulatory Receptor 4-1BB Protects Against Obesity-Induced Inflammation and Metabolic Disorders
OBJECTIVE Inflammation is an important factor in the development of insulin resistance, type 2 diabetes, and fatty liver disease. As a member of the tumor necrosis factor receptor superfamily (TNFRSF9) expressed on immune cells, 4-1BB/CD137 provides a bidirectional inflammatory signal through binding to its ligand 4-1BBL. Both 4-1BB and 4-1BBL have been shown to play an important role in the pa...
متن کاملCutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin.
A hallmark of autoimmune lymphoproliferative syndrome (ALPS), caused by mutation of the Fas death receptor, is massive lymphadenopathy from aberrant expansion of CD4(-)CD8(-) (double-negative [DN]) T cells. Eomesodermin (Eomes) is a member of the T-box family of transcription factors and plays critical roles in effector cell function and memory cell fitness of CD8(+) T lymphocytes. We provide e...
متن کاملHow I treat How I treat EBV lymphoproliferation
Epstein-Barr virus (EBV)–associated Bcell lymphoproliferation is a life-threatening complication after hematopoietic stem cell or solid organ transplantation resulting from outgrowth of EBV-infected B cells that would normally be controlled by EBVcytotoxic T cells. During the past decade, early detection strategies, such as serial measurement of EBV-DNA load in peripheral blood samples, have he...
متن کاملInhibition of EBV-induced lymphoproliferation by CD4(+) T cells specific for an MHC class II promiscuous epitope.
Posttransplant lymphoproliferative disorder (PTLD) and B cell lymphomas induced by EBV continue to be a major life-threatening complication in transplant patients. The establishment and enhancement of T cell immunity to EBV before transplantation and immunosuppressive therapy could help diminish these complications, but the lack of an effective vaccine has limited this prophylactic approach. We...
متن کاملTowards gene therapy for EBV-associated Post-Transplant Lymphoproliferative disease: genetically modified EBV-specific Cytotoxic T Lymphocytes induce regression of autologous EBV-induced Lymphoproliferation despite immunosuppression
Towards gene therapy for EBV-associated Post-Transplant Lymphoproliferative disease: genetically modified EBV-specific Cytotoxic T Lymphocytes induce regression of autologous EBV-induced Lymphoproliferation despite immunosuppression. Ida Ricciardelli , Michael Patrick Blundell , Jennifer Brewin , Martin Pule *, Persis J. Amrolia * 1 Molecular and Cellular Immunology Unit, Institute of Child Hea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2019
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2019.03.002